3-Pyridinecarboxylic acid, 2-methyl-6-(trifluoromethyl)-
2-Methyl-6-(trifluoromethyl)nicotinic acid
CAS: 261635-93-2
Molecular Formula: C8H6F3NO2
3-Pyridinecarboxylic acid, 2-methyl-6-(trifluoromethyl)- - Names and Identifiers
3-Pyridinecarboxylic acid, 2-methyl-6-(trifluoromethyl)- - Physico-chemical Properties
| Molecular Formula | C8H6F3NO2 |
| Molar Mass | 205.13 |
| Density | 1.414±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 139-141℃ |
| Boling Point | 253.0±40.0℃ (760 Torr) |
| Flash Point | 106.8±27.3℃ |
| Water Solubility | Slightly soluble in water (4.7 g/L at 25°C). |
| Vapor Presure | 0.01mmHg at 25°C |
| pKa | 2.51±0.25(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.479 |
3-Pyridinecarboxylic acid, 2-methyl-6-(trifluoromethyl)- - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Note | Corrosive |
| Hazard Class | IRRITANT |
3-Pyridinecarboxylic acid, 2-methyl-6-(trifluoromethyl)- - Introduction
2-Methyl-6-(trifluoromethyl)nicotinic acid is an organic compound with the chemical formula C8H6F3NO2.
Nature:
-Appearance: Colorless or yellowish solid
-Melting point: 118-120 ° C
-Solubility: Soluble in ethanol, dichloromethane and chloroform, almost insoluble in water
Use:
2-Methyl-6-(trifluoromethyl)nicotinic acid is an important intermediate compound used in pesticide and pharmaceutical fields. It can be used as an antifungal agent to protect crops from fungal infections. In addition, it can also be used as a starting material for the synthesis of various organic compounds.
Method:
2-Methyl-6-(trifluoromethyl)nicotinic acid can be prepared by the following reaction:
1. Under alkaline conditions, P-toluenesulfonic acid is substituted to give 2-methyl -6-sulfonic acid pyridine.
2. A trifluoromethane group is introduced into 2-methyl-6-sulfopyridine by a trifluoromethylation reaction to obtain 2-methyl-6-trifluoromethylpyridine.
3. Finally, the amino group was introduced into 2-Methyl-6-trifluoromethylpyridine by amination reaction under heating acid catalyst to give 2-Methyl-6-(trifluoromethyl)nicotinic acid.
Safety Information:
2-Methyl-6-(trifluoromethyl)nicotinic acid is irritating and may cause eye and skin irritation when exposed. In the use of the process, should avoid inhalation of dust or contact with the skin, do a good job of personal protective measures. If contact occurs, rinse immediately with plenty of water and seek medical help if necessary.
Nature:
-Appearance: Colorless or yellowish solid
-Melting point: 118-120 ° C
-Solubility: Soluble in ethanol, dichloromethane and chloroform, almost insoluble in water
Use:
2-Methyl-6-(trifluoromethyl)nicotinic acid is an important intermediate compound used in pesticide and pharmaceutical fields. It can be used as an antifungal agent to protect crops from fungal infections. In addition, it can also be used as a starting material for the synthesis of various organic compounds.
Method:
2-Methyl-6-(trifluoromethyl)nicotinic acid can be prepared by the following reaction:
1. Under alkaline conditions, P-toluenesulfonic acid is substituted to give 2-methyl -6-sulfonic acid pyridine.
2. A trifluoromethane group is introduced into 2-methyl-6-sulfopyridine by a trifluoromethylation reaction to obtain 2-methyl-6-trifluoromethylpyridine.
3. Finally, the amino group was introduced into 2-Methyl-6-trifluoromethylpyridine by amination reaction under heating acid catalyst to give 2-Methyl-6-(trifluoromethyl)nicotinic acid.
Safety Information:
2-Methyl-6-(trifluoromethyl)nicotinic acid is irritating and may cause eye and skin irritation when exposed. In the use of the process, should avoid inhalation of dust or contact with the skin, do a good job of personal protective measures. If contact occurs, rinse immediately with plenty of water and seek medical help if necessary.
Last Update：2024-04-09 21:00:56
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CAS: 261635-93-2
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